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Wei Xie’s group published research on…

During early mammalian development, the totipotent zygote undergoes the first cell fate decision to form a blastocyst that includes inner cell mass (ICM) and trophectoderm (TE). ICM will give rise to epiblast, which generates all future embryonic lineages, and primitive endoderm (PrE), which forms future yolk sac. By contrast, trophectoderm primarily differentiates to the placenta that supports...

01 Sep

Guangshuo Ou’s group published resear…

Guangshou Ou’s group at School of Life Sciences at Tsinghua University published an article entitled "Modulation of inner junction proteins contributes to axoneme differentiation" in the journal Proceedings of the National Academy of Sciences of the United States of America (PNAS) on July 18, 2023, reporting on the mechanism and function of axoneme differentiation.Cilia are organelles widely d...

18 Dec

Qiaoran Xi's group and Yi Lin's group …

The transforming growth factor β (TGF-β) signaling pathway plays important roles in the regulation of tissue homeostasis, immune response, tumorigenesis and early mammalian mesodermal differentiation. It has been reported that TRIM33, as a member of TRIM family, plays a key role in the Nodal signaling pathway and regulates mesendoderm differentiation. The protein levels of TRIM33 had no obvio...

06 Oct

Zhucheng Chen’s group and collaborato…

DNA in eukaryotes wraps around the histone octamer by ~1.7 turns to form nucleosomes, the fundamental unit of chromatin. The N-termini of histone H4 interact with nearby nucleosomes, and play an important role in the formation of high order chromatin structure and heterochromatin silencing. The formation of nucleosome and heterochromatin hinders genomic DNA functions, such as replication, trans...

24 Sep

Qiaoran Xi’s group published research…

Transforming growth factor β (TGF-β) superfamily proteins are potent regulators of cellular development and differentiation. Nodal/Activin/TGF-β and BMP ligands are both present in the intra- and extracellular milieu during early development, and cross-talk between these two branches of developmental signaling is currently the subject of intense research focus.The heart is one of the earlies...

22 Sep

Jijie Chai and collaborators publish a…

During the long-term fighting against pathogens, plants have evolved a sophisticated innate immune system to defend against infection. Plants pattern recognition receptors (PRRs) sense pathogen-associated molecular patterns (PAMPs) or host-derived danger-associated molecular patterns (DAMPs) to activate an immune response termed pattern-triggered immunity (PTI). PRRs are mainly composed of rece...

09 Sep

Wei Xie’s group, Zi-Jiang Chen’s gro…

A joint team led by Prof. Wei Xie at Tsinghua University, Prof. Zi-Jiang Chen and Prof. Han Zhao from Shandong University, has charted the translational landscapes during the human oocyte-to-embryo transition (OET). This dataset further identified a group of homeobox TFs, including TPRXL, TPRX1, and TPRX2, which are highly translated around ZGA, and are required for proper ZGA and preimplantati...

03 Aug

Qiaoran Xi’s group and Liwei Zhang’s…

Diffuse intrinsic pontine glioma (DIPG) is a rare and incurable pediatric brain cancer with survival of less than one year. Understanding the tumorigenesis mechanisms of DIPG and identifying potential new therapeutic strategy are major research foci in the DIPG field.On August 01, 2022, Qiaoran Xi’s research group from Tsinghua University and Liwei Zhang’s research group from Beijing Tiantan ...

13 Jul

The transcriptional regulatory functio…

Despite the fundamental roles of TGF-β family signaling in cell fate determination in all metazoans, the mechanism by which these signals are spatially and temporally interpreted remains elusive. The cell context-dependent function of TGF-β signaling largely relies on transcriptional regulation by SMAD proteins.On July 12, 2022, Qiaoran Xi’s research group from Tsinghua University published ...