科研成果

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• Directed evolution and selection of biostable L-DNA aptamers with a mirror-image DNA polymerase

  Chen, Ji; Chen, Mengyin; Zhu, Ting F.

  NATURE BIOTECHNOLOGY

• CCT2 is an aggrephagy receptor for clearance of solid protein aggregates

  Ma, Xinyu; Lu, Caijing; Chen, Yuting; Li, Shulin; Ma, Ningjia; Tao, Xuan; Li, Ying; Wang, Jing; Zhou, Min; Yan, Yong-Bin; Li, Pilong; Heydari, Kartoosh; Deng, Haiteng; Zhang, Min; Yi, Cong; Ge, Liang

  CELL

• Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation

  Shen, Weimin; Gong, Bo; Xing, Cencan; Zhang, Lin; Sun, Jiawei; Chen, Yuling; Yang, Changmei; Yan, Lu; Chen, Luxi; Yao, Likun; Li, Guangyuan; Deng, Haiteng; Wu, Xiaotong; Meng, Anming

  CELL

• Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs

  Xu, Yuan; Zhu, Ting F.

  SCIENCE

• Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity

  Huang, Shijia; Jia, Aolin; Song, Wen; Hessler, Giuliana; Meng, Yonggang; Sun, Yue; Xu, Lina; Laessle, Henriette; Jirschitzka, Jan; Ma, Shoucai; Xiao, Yu; Yu, Dongli; Hou, Jiao; Liu, Ruiqi; Sun, Huanhuan; Liu, Xiaohui; Han, Zhifu; Chang, Junbiao; Parker, Jane E.; Chai, Jijie

  SCIENCE

• TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity

  Jia, Aolin; Huang, Shijia; Song, Wen; Wang, Junli; Meng, Yonggang; Sun, Yue; Xu, Lina; Laessle, Henriette; Jirschitzka, Jan; Hou, Jiao; Zhang, Tiantian; Yu, Wenquan; Hessler, Giuliana; Li, Ertong; Ma, Shoucai; Yu, Dongli; Gebauer, Jan; Baumann, Ulrich; Liu, Xiaohui; Han, Zhifu; Chang, Junbiao; Parker, Jane E.; Chai, Jijie

  SCIENCE

• Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation

  Zou, Zhuoning; Zhang, Chuanxin; Wang, Qiuyan; Hou, Zhenzhen; Xiong, Zhuqing; Kong, Feng; Wang, Qiujun; Song, Jinzhu; Liu, Boyang; Liu, Bofeng; Wang, Lijuan; Lai, Fangnong; Fan, Qiang; Tao, Wenrong; Zhao, Shuai; Ma, Xiaonan; Li, Miao; Wu, Keliang; Zhao, Han; Chen, Zi-Jiang; Xie, Wei

  SCIENCE

• Advances and opportunities in RNA structure experimental determination and computational modeling

  Zhang, Jinsong; Fei, Yuhan; Sun, Lei; Zhang, Qiangfeng Cliff

  NATURE METHODS

• Structure of the NuA4 acetyltransferase complex bound to the nucleosome

  Qu, Keke; Chen, Kangjing; Wang, Hao; Li, Xueming; Chen, Zhucheng

  NATURE

• Structure of human chromatin-remodelling PBAF complex bound to a nucleosome

  Yuan, Junjie; Chen, Kangjing; Zhang, Wenbo; Chen, Zhucheng

  NATURE

• Patterned cPCDH expression regulates the fine organization of the neocortex

  Lv, Xiaohui; Li, Shuo; Li, Jingwei; Yu, Xiang-Yu; Ge, Xiao; Li, Bo; Hu, Shuhan; Lin, Yang; Zhang, Songbo; Yang, Jiajun; Zhang, Xiuli; Yan, Jie; Joyner, Alexandra L.; Shi, Hang; Wu, Qiang; Shi, Song-Hai

  NATURE

• Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex

  Dong, Xiaoxiang; Zhang, Qiangqiang; Yu, Xiangyu; Wang, Ding; Ma, Jiaming; Ma, Jian; Shi, Song-Hai

  NATURE NEUROSCIENCE

• Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development

  Xiong, Zhuqing; Xu, Kai; Lin, Zili; Kong, Feng; Wang, Qiujun; Quan, Yujun; Sha, Qian-qian; Li, Fajin; Zou, Zhuoning; Liu, Ling; Ji, Shuyan; Chen, Yuling; Zhang, Hongmei; Fang, Jianhuo; Yu, Guang; Liu, Bofeng; Wang, Lijuan; Wang, Huili; Deng, Haiteng; Yang, Xuerui; Fan, Heng-yu; Li, Lei; Xie, Wei

  NATURE CELL BIOLOGY

• Assembly of Tetraspanin-enriched macrodomains contains membrane damage to facilitate repair

  Huang, Yuwei; Zhang, Xing; Wang, Hong-Wei; Yu, Li

  NATURE CELL BIOLOGY

• Monocytes deposit migrasomes to promote embryonic angiogenesis

  Zhang, Cuifang; Li, Tianqi; Yin, Shuyao; Gao, Mingyi; He, Helen; Li, Ying; Jiang, Dong; Shi, Minghui; Wang, Jianbin; Yu, Li

  NATURE CELL BIOLOGY

• A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells

  Zuo, Feifei; Jiang, Junyi; Fu, Haipeng; Yan, Kun; Liefke, Robert; Zhang, Jing; Hong, Yaqiang; Chang, Zai; Liu, Nian; Wang, Zhanxin; Xi, Qiaoran

  CELL STEM CELL

• The second polar body contributes to the fate asymmetry in the mouse embryo

  Jin, Hongbin; Han, Yang; Wang, Huasong; Li, J. Xiao He; Shen, Weimin; Zhang, Lin; Chen, Luxi; Jia, Shunji; Yuan, Ping; Chen, Hui; Meng, Anming

  NATIONAL SCIENCE REVIEW

• Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5

  Sun, Ye; Yan, Kun; Wang, Yi; Xu, Cheng; Wang, Dan; Zhou, Wei; Guo, Shuning; Han, Yujie; Tang, Lei; Shao, Yanqiu; Shan, Shaobo; Zhang, Qiangfeng C.; Tang, Yujie; Zhang, Liwei; Xi, Qiaoran

  NATURE CANCER

• Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate

  Zhao, Mengjia; Yao, Pengbo; Mao, Youxiang; Wu, Jinjun; Wang, Weihua; Geng, Chenhui; Cheng, Jie; Du, Wenjing; Jiang, Peng

  NATURE METABOLISM

• An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment

  Yang, Bing; Zhang, Zhen; Chen, Xiangjun; Wang, Xu-Yan; Qin, Shishang; Du, Liaoqi; Yang, Changjiang; Zhu, Liyu; Sun, Wenbo; Zhu, Yongjie; Zheng, Qinwen; Zhao, Shidong; Wang, Quan; Zhao, Long; Lin, Yilin; Huang, Jinghe; Wu, Fan; Lu, Lu; Wang, Fei; Zheng, Wenjie; Zhou, Xiao-Hua; Zhao, Xiaozhen; Wang, Ziye; Sun，Xiao-Lin; Ye, Yingjiang; Wang, Shan; Li, Zhanguo; Qi, Hai; Zhang, Zemin; Kuang, Dong-Ming; Zhang, Lei; Shen, Zhanlong; Liu, Wanli

  THE JOURNAL OF CLINICAL INVESTIGATION

• Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity

  Tsuchida, Connor A.; Zhang, Shouyue; Doost, Mohammad Saffari; Zhao, Yuqian; Wang, Jia; O'Brien, Elizabeth; Fang, Huan; Li, Cheng-Ping; Li, Danyuan; Hai, Zhuo-Yan; Chuck, Jonathan; Brötzmann, Julian; Vartoumian, Araz; Burstein, David; Chen, Xiao-Wei; Nogales, Eva; Doudna, Jennifer A.; Liu, Jun-Jie Gogo

  MOLECULAR CELL