江鹏 博士

副教授

1999-2003年 安徽大学生物技术系 学士

2003-2008年 中国科学技术大学分子细胞生物学系 博士

2008-2013年 美国宾夕法尼亚大学医学院 博士后
2013-2014年 美国宾夕法尼亚大学医学院 Research Associate

2014-2021年 beat365官方网站 助理教授

2021-         beat365官方网站 副教授

2020-         清华-北大生命科学联合中心，PI

●  研究兴趣、领域：

肿瘤和免疫代谢。实验室主要研究肿瘤和免疫细胞中代谢异常发生的调控机制，以及细胞感知微环境中代谢物质改变的分子机制和生理、病理功能。

 

●  代表性论文：

1. Xu X, Wang J, Xu L, Li P*, Jiang P*. p53 suppresses lipid droplet-fueled tumorigenesis through phosphatidylcholine. J Clin Invest. 2024 Jan 9;134(4).

2. Chen T#, Xie S#, Cheng J, Zhao Q, Wu H*, Jiang P*, Du W*. AKT1 phosphorylation of cytoplasmic ME2 induces a metabolic switch to glycolysis for tumorigenesis. Nat Communs. (2024) Jan 23;15(1):686.

3. Xia W, Jiang P*. p53 promotes antiviral innate immunity by driving hexosamine metabolism. Cell Reports. (2024) Jan 30;43(2):113724.

4. Cheng J#, Yan J#, Liu Y#, Shi J#, Wang H, Zhou H, Zhou Y, Zhang T, Zhao L, Meng X, Gong H, Zhang X*, Zhu H*, Jiang P*. Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment. Cell Metabolism. (2023) Jun 6;35(6):961-978.

5. Cheng, J#, Liu, Y#, Yan, J#, Zhao L, Zhou Y, Shen X, Y, Chen Y, Meng X, Zhang X* & Jiang P*. Fumarate suppresses B-cell activation and function through direct inactivation of LYN. Nature Chemical Biology (2022). Sep;18(9):954-962.

6. Zhao M#, Yao P#, Mao Y#, Wu J#, Wang W, Geng C, Cheng J, Du W * and Jiang P*. Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate. Nature Metabolism. (2022). Feb;4(2):225-238.

7. Mao Y, Shi D, Li G, Jiang P*. Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses. Molecular Cell. (2022) Feb 3;82(3):527-541.

8. Li G#, Wu J#, Li L, Jiang P*. p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage. Proc Natl Acad Sci U S A. (2021) Jul 13;118(28)

9. Wu J#, Li G#, Li L, Li D, Dong Z, Jiang P*. Asparagine enhances LCK signalling to potentiate CD8+ T cell-activation and anti-tumour responses. Nature Cell Biology, (2021) 23(1):75-86.

10. Deng L, Yao P, Li L, Ji F, Zhao S, Xu C, Lan X, Jiang P*. p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival. Nature Communs, (2020) 11, 1755-18;

11. Li L, Mao Y, Zhao L, Li L, Wu J, Zhao M, Du W, Yu L, Jiang P*. p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis. Nature. (2019) 567(7747):253-256.

12. Li L#, Li L#, Li W, Chen T, Bin Zou, Zhao L, Wang H, Wang X, Xu L, Liu X, Wang D, Li B, Mak TW, Du W*, Yang X*, Jiang P*. TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation. Nature Communs. (2018), Nov 8; 9(1):4683.

13. Du W#, Jiang P#, Mancuso A, Stonestrom A, Brewer M, Minn AJ, Mak TW, Wu M* and Yang X*. TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nature Cell Biology. (2013), Aug. 15, 991–1000.

14. Jiang P#, Du W#, Mancuso A, Wellen KE, Yang X*. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. (2013), Jan. 493: 689-693.

15. Jiang P#, Du W#, Wang X, Mancuso A, Gao X, Wu M* and Yang X*. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nature Cell Biology. (2011) Mar.13: 310-316.

●  联系方式：

Email: jiang-lab@mail.tsinghua.edu.cn
Phone:010-62786079 (Office), or 010-62783063 (Laboratory)