李丕龙 博士
副教授
1996-2000 |
北京大学 |
学士 |
2000-2002 |
香港科技大学 |
硕士 |
2002-2009 |
德克萨斯大学西南医学中心 |
博士 |
2009-2010 |
德克萨斯大学西南医学中心 |
博士后 |
2010-2015 |
宾夕法尼亚大学 |
博士后 |
2016-至今 |
beat365官方网站 |
助理教授、副教授
|
● 研究兴趣、领域：
相分离现象的普适化调控机制与规律
相分离在自噬、转录调控、表观遗传等领域的生物学意义
基于相分离的技术开发与应用
● 开设的课程：
生物大分子“相变”研究进展
● 代表性论文：
1. Li R, Li T, Lu G, Cao Z, Chen B, Wang Y, Du J*, Li P*. (2022) Programming cell-surface signaling by phase-separation-controlled compartmentalization. Nat Chem Biol. 18:1351-1360.
2. Buttress T#, He S#, Wang L#, Zhou S#, Saalbach G, Vickers M, Li G, Li P*, Feng X*. Histone H2B.8 compacts flowering plant sperm through chromatin phase separation. (2022) Nature. 611:614-622.
3. Chen Z, Hou C, Wang L, Yu C, Chen T, Shen B, Hou Y, Li P*, Li T*. (2022) Screening membraneless organelle participants with machine-learning models that integrate multimodal features. Proc Natl Acad Sci U S A. 119:e2115369119.
4. Feng X, Du W, Ding M, Zhao W, Xirefu X, Ma M, Zhuang Y, Fu X, Shen J, Zhang J, Lei X, Sun D, Xi Q, Aisa Y, Chen Q, Li Y, Wang W, Huang S, Yu L, Li P*, Mi N*. (2022) Myosin 1D and the branched actin network control the condensation of p62 bodies. Cell Res. 32:659-669.
5. Xu W#, Pei G#, Liu H#, Ju X, Wang J, Ding Q, Li P*. (2021) Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteome. Cell Rep. 36:109482.
6. Huang X#, Chen S#, Li W, Tang L, Zhang Y, Yang N, Zou Y, Zhai X, Xiao N, Liu W, Li P*, Xu C*. (2021) ROS regulated reversible protein phase separation synchronizes plant flowering. Nat Chem Bio. 17:549-557.
7. Zuo L, Zhang G, Massett M, Cheng J, Wang L, Gao Y, Li R, Huang X*, Li P*, Qi Z*. (2021) Loci-specific phase separation of FET fusion oncoproteins promotes aberrant gene transcription. Nat Commun. 12:1491.
8. Zhou M#, Li W#, Li J#, Xie L, Wu R, Wang L, Fu S, Su W, Hu J, Wang J, Li P*. (2020) Phase-separated condensate-aided enrichment of biomolecular interactions for high-throughput drug screening in test tubes. J Biol Chem. 295:11420-11434.
9. Wang L#, Hu M#, Zuo M, Zhao J, Wu D, Huang L, Wen Y, Li Y, Chen P, Bao X, Dong M, Li G*, Li P*. (2020) Rett syndrome mutations compromise MeCP2-mediated liquid-liquid phase separation of chromatin. Cell Res. 30:393-407.
10. Fang X#, Wang L#, Ishikawa R#, Li Y, Fiedler M, Liu F, Calder G, Rowan B, Weigel D, Li P*, Dean C*. (2019) Arabidopsis FLL2 promotes liquid–liquid phase separation of polyadenylation complexes. Nature. 569:265-269.
11. Gao Y#, Pei G#, Li D#, Li R, Shao Y, Zhang QC, Li P*. (2019) Multivalent m6A motifs promote phase separation of YTHDF proteins. Cell Res. 29:767-769.
12. Wang L#, Gao Y#, Zheng X#, Liu C, Dong S, Li R, Zhang G, Wei Y, Qu H, Li Y, Allis CD, Li G, Li H*, Li P*. (2019) Histone modifications regulate chromatin compartmentalization by contributing to a phase separation mechanism. Mol Cell. 76:646-659.
13. Sun D#, Wu R#, Zheng J, Li P*, Yu L*. (2018) Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation. Cell Res. 28:405-415.
14.Li P#, Banjade S#, Cheng HC#, Kim S, Chen B, Guo L, Llaguno M, Hollingsworth JV, King DS, Banani SF, Russo PS, Jiang QX, Nixon BT, Rosen MK*. (2012) Phase transitions in the assembly of multivalent signalling proteins. Nature. 483:336-340.
#: equal contribution; *: corresponding authorship
● 荣誉、奖励及参加学术团体的情况：
现任中国生物物理学会生物大分子相分离与相变分会副理事长; Molecular Cell杂志编委会成员; Biochemical Journal杂志副编辑（Associate Editor）; Cell，Science等杂志的审稿人。
● 联系方式：
电话：＋86-10-62794071（实验室）
电子邮件：pilongli/at/mail.tsinghua.edu.cn
