施一公 博士

教授   中国科学院院士   美国科学院外籍院士   美国艺术与科学院外籍院士

●  研究兴趣、领域：

主要运用结构生物学、生物化学和生物物理的手段研究RNA剪接、细胞凋亡等细胞内生物大分子机器的结构与功能，以及γ-分泌酶介导的阿尔茨海默症的分子机制。

●  代表性论文 (# indicates corresponding authors)：

1. Guanghui Yang, Rui Zhou, Xuefei Guo, Chuangye Yan, Jianlin Lei, Yigong Shi^# (2021). Structural basis of γ-secretase inhibition and modulation by small molecule drugs. Cell, 184(2):521-533.

2. Gaoxingyu Huang, Yanqing Zhang, Xuechen Zhu, Chao Zeng, Qifan Wang, Qiang Zhou, Qinghua Tao, Minhao Liu, Jianlin Lei, Chuangye Yan and Yigong Shi^# (2020). Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis. Cell Research, 30(6):520–531.

3. Rui Zhou, Guanghui Yang, Xuefei Guo, Qiang Zhou, Jianlin Lei, Yigong Shi^# (2019). Recognition of the amyloid precursor protein by human γ-secretase. Science, 363(6428):eaaw0930.

4. Guanghui Yang, Rui Zhou, Qiang Zhou, Xuefei Guo, Chuangye Yan, Meng Ke, Jianlin Lei & Yigong Shi^# (2019). Structural basis of Notch recognition by human γ-secretase. Nature, 565(7738):192-197.

5. Rui Bai, Ruixue Wan, Chuangye Yan, Jianlin Lei, Yigong Shi^# (2018). Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation. Science, 360(6396):1423-1429.

6. Xiechao Zhan, Chuangye Yan^#, Xiaofeng Zhang, Jianlin Lei, Yigong Shi^# (2018). Structure of a human catalytic step I spliceosome. Science, 359(6375): 537-545.

7. Xiaofeng Zhang, Chuangye Yan^#, Jing Hang, Lorenzo I. Finci, Jianlin Lei, and Yigong Shi^# (2017). An atomic structure of the human spliceosome. Cell, 169(5):918-929.

8. Rui Bai, Chuangye Yan, Ruixue Wan, Jianlin Lei, and Yigong Shi^# (2017). Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae. Cell, 171(7):1589-1598.

9. Chuangye Yan, Ruixue Wan, Rui Bai, Gaoxingyu Huang, Yigong Shi^# (2016). Structure of a yeast catalytically activated spliceosome at 3.5 Å resolution. Science, 353(6302):904-911.

10. Ruixue Wan, Chuangye Yan, Rui Bai, Gaoxingyu Huang, Yigong Shi^# (2016). Structure of a yeast catalytic step I spliceosome at 3.4 Å resolution. Science, 353(6302):895-904.

11. Chuangye Yan, Jing Hang, Ruixue Wan, Min Huang, Catherine C. L. Wong, Yigong Shi^# (2015). Structure of a yeast spliceosome at 3.6-angstrom resolution. Science, 349(6253):1182-1191.

12. Jing Hang, Ruixue Wan, Chuangye Yan, and Yigong Shi^# (2015). Structural basis of pre-mRNA splicing. Science, 349(6253):1191-1198.

13. Mengying Zhou, Yini Li, Qi Hu, Xiaochen Bai, Weijiao Huang, Chuangye Yan, Sjors H. W. Scheres^#, and Yigong Shi^# (2015). Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1. Genes & Development, 29(22):2349-2361.

14. Peilong Lu, Xiao-chen Bai, Dan Ma, Tian Xie, Chuangye Yan, Linfeng Sun, Guanghui Yang, Yanyu Zhao, Rui Zhou, Sjors H. W. Scheres^# & Yigong Shi^# (2014). Three-dimensional structure of human γ-secretase. Nature, 512(7513): 166-170.

15. Shiqian Qi, Yuxuan Pang, Qi Hu, Qun Liu, Hua Li, Yulian Zhou, Tianxi He, Qionglin Liang, Yexing Liu, Xiaoqiu Yuan, Guoan Luo, Huilin Li, Jiawei Wang, Nieng Yan^#, and Yigong Shi^# (2010). Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell, 141(3):446-457.

●  联系方式：

电话：+86-10-62797560(实验室)
E-mail: shi-lab@mail.tsinghua.edu.cn
Web: https://ygshi.org