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刘万里博士

教授

1997 – 2001 中国农业大学生物学院学士

2001 – 2005 清华大学生物科学与技术系博士

2005 – 2007 美国加州大学旧金山分校(UCSF)微生物与免疫学系博士后

2007 – 2011 美国国立卫生研究院(NIH)过敏与传染病研究所(NIAID) 博士后

2011.12 – beat365官方网站副教授、教授

● 研究兴趣、领域：

应用高速高分辨率的活细胞单分子荧光成像技术，并结合传统的免疫学、分子细胞、生物化学和生物物理研究手段，致力于B淋巴细胞机制和功能研究：（1）B淋巴细胞免疫识别和免疫活化的分子机制及调控机制的研究；（2）B淋巴细胞异常活化导致的自身免疫疾病及淋巴癌和白血病的研究；（3）B淋巴细胞生成-储存-读取长效型抗体记忆的研究；（4）B淋巴细胞依赖机械力感知调控免疫活化和功能的研究；（5）病原微生物作用于B淋巴细胞早期活化途径的免疫逃逸的研究；（6）整合攻关基于上述研究结果的新型疫苗和新型药物。

● 代表性论文：

* 通讯作者（仅列入就职清华以来的研究论文）

[1] Bing Yang#, Zhen Zhang#, Xiangjun Chen#, Xu-Yan Wang, Shishang Qin, Liaoqi Du, Changjiang Yang, Liyu Zhu, Wenbo Sun, Yongjie Zhu, Qinwen Zheng, Shidong Zhao, Quan Wang, Long Zhao, Yilin Lin, Jinghe Huang, Fan Wu, Lu Lu, Fei Wang, Wenjie Zheng, Xiao-Hua Zhou, Xiaozhen Zhao, Ziye Wang, Sun Xiao-Lin, Yingjiang Ye, Shan Wang, Zhanguo Li, Hai Qi, Zemin Zhang, Dong-Ming Kuang, Lei Zhang, Zhanlong Shen*, Wanli Liu*. An Asian-specific variant in human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment. J Clin Invest. 2022, e153454. doi: 10.1172/JCI153454. (featured article with a preview commentary)

[2] Jing Chen#, Xiaochen Zhang#, Liping Li#, Xianqiang Ma, Chunxiao Yang, Zhaodi Liu, Chenyang Li, Maria J. Fernandez-Cabezudo, Basel K. al-Ramadi, Chuan Wu, Weishan Huang, Yong Zhang*, Yonghui Zhang*, Wanli Liu*. Farnesyl pyrophosphate is a new danger signal inducing acute cell death. PLoS Biology. 2021, 19:e3001134. doi: 10.1371/journal.pbio.3001134. (featured article with an editor’s digest)

[3] Xingwang Zhao#, Hengyi Xie#, Meng Zhao#, Asma Ahsan, Xinxin Li, Fei Wang, Junyang Yi, Zhiyong Yang, Chuan Wu, Indu Raman, Quan-Zhen Li*, Tae Jin Kim*, Wanli Liu*. Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function. Science Advances. 2019, 5, eaaw0315, DOI: 10.1126/sciadv.aaw0315

[4] Zhixun Shen#, Sichen Liu#, Xinxin Li#, Zhengpeng Wan, Youxiang Mao, Chunlai Chen, Wanli Liu*. Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding. eLife. 2019, 8, doi: 10.7554/eLife.42271.

[5] Chenguang Xu#, Yan Fang#, Zhiyong Yang, Yukai Jing, Yonghui Zhang, Chaohong Liu*, Wanli Liu*. MARCKS regulates tonic and chronic active B cell receptor signaling. Leukemia. 2019, 33:710-729.

[6] Xiangjun Chen, Xiaolin Sun#, Wei Yang#, Bing Yang#, Xiaozhen Zhao, Shuting Chen1, Lili He, Hui Chen, Changmei Yang, Le Xiao, Zai Chang, Jianping Guo, Jing He, Fuping Zhang, Fang Zheng, Zhibin Hu, Zhiyong Yang, Jizhong Lou, Wenjie Zheng, Hai Qi, Chenqi Xu, Hong Zhang, Hongying Shan, Xu-jie Zhou, Qingwen Wang, Yi Shi, Luhua Lai, Zhanguo Li *, Wanli Liu*. An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation. Science. 2018, 362:700-705. (Nature Reviews Rheumatology, Research Highlights)

[7] Yun Xia#, Yonghua Xie#, Zhengsen Yu#, Hongying Xiao, Guimei Jiang, Xiaoying Zhou, Yunyun Yang, Xin Li, Meng Zhao, Liping Li, Mingke Zheng, Shuai Han, Zhaoyun Zong, Xianbin Meng, Haiteng Deng, Huahu Ye, Yunzhi Fa, Haitao Wu, Eric Oldfield, Xiaoyu Hu, Wanli Liu*, Yan Shi*, Yonghui Zhang*. The mevalonate pathway is a druggable target for vaccine adjuvant discovery. Cell. 2018, 175:1059-1073. (Nature Reviews Immunology, Research Highlights)

[8] Junyi Wang#, Feng Lin#, Zhengpeng Wan, Xiaolin Sun, Yun Lu, Jianyong Huang, Fei Wang, Yingyue Zeng, Ying-Hua Chen, Yan Shi, Wenjie Zheng, Zhanguo Li, Chunyang Xiong*, Wanli Liu*. Profiling the origin, dynamics, and function of traction force in B cell activation. Science Signaling. 2018, 11. pii: eaai9192. doi: 10.1126/scisignal.aai9192.

[9] Zhengpeng Wan, Chenguang Xu#, Xiangjun Chen#, Hengyi Xie#, Zongyu Li#, Jing Wang#, Xingyu Ji, Haodong Chen, Qinghua Ji, Samina Shaheen, Yang Xu, Fei Wang, Zhuo Tang, Ji-Shen Zheng, Wei Chen, Jizhong Lou, Wanli Liu*. PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation. J Cell Biol. 2018, 217:2565-2582.

[10] Chenguang Xu, Hengyi Xie, Xingdong Guo, Haipeng Gong, Lei Liu, Hai Qi, Chenqi Xu, Wanli Liu*. A PIP2-derived amplification loop fuels the sustained initiation of B cell activation. Science Immunology. 2017, 2. pii: eaan0787. doi: 10.1126/sciimmunol.aan0787. (featured article, editor’s choice)

[11] Jing Wang, Liling Xu, Samina Shaheen, Sichen Liu, Wenjie Zheng, Xiaolin Sun, Zhanguo Li, Wanli Liu*. Growth of B cell receptor microclusters is regulated by PIP2 and PIP3 equilibrium and Dock2 recruitment and activation. Cell Reports. 2017, 21:2541-2557.

[12] Liling Xu#, Mengdie Xia#, Jun Guo#, Xiaolin Sun#, Hua Li, Chenguang Xu, Xiaomei Gu, Haowen Zhang, Junyang Yi, Yan Fang, Hengyi Xie, Jing Wang, Zhixun Shen, Boxin Xue, Yujie Sun, Tobias Meckel, Ying-Hua Chen, Zhibin Hu, Zhanguo Li*, Chenqi Xu*, Haipeng Gong*, Wanli Liu*. Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232. J Exp Med. 2016, 213:2707-2727.

[13] Jing Wang#, Shan Tang#, Zhengpeng Wan, Yiren Gao, Yiyun Cao, Junyang Yi, Yanyan Si, Haowen Zhang, Lei Liu* and Wanli Liu*. Utilization of a photoactivatable antigen system to examine B cell probing termination and the B cell receptor sorting mechanisms during B cell activation. PNAS. 2016, 113:E558-567.

[14] Zhengpeng Wan, Xiangjun Chen, Haodong Chen, Qinghua Ji, Yingjia Chen, Jing Wang, Yiyun Cao, Fei Wang, Jizhong Lou, Zhuo Tang and Wanli Liu*. The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold. eLife. 2015, 4:e06925 (Faculty of 1000 recommended paper)

[15] Xiangjun Chen#, Weiling Pan#, Yinqiang Sui, Hua Li, Xiaoshan Shi, Xingdong Guo, Hai Qi, Chenqi Xu* and Wanli Liu*. Acidic phospholipids govern the enhanced activation of IgG-B cell receptor. Nature Communications. 2015, 6:8552.