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Daoxin XIE Ph.D.

Professor Academician of the Chinese Academy of Sciences

2006-present: Professor, Tsinghua University

2002-2006: Senior Scientist, Principal Investigator, Institute of Molecular and Cell Biology, Singapore

1999-2002: Senior Scientist, Principal Investigator, Institute of Molecular Agrobiology; Adjunct Assistant Professor, National University of Singapore

1994-1999: Senior Research Associate (Postdoc), University of East Anglia, UK

1990-1994: Postdoctoral Researcher, John Innes Centre; Leicester University, UK

1984-1990: Ph.D. and MSc., Chinese Academy of Agricultural Sciences

1983-1984: Research Assistant, Hunan Cotton Research Institute

1979-1983: BSc., Hunan Agricultural College

Research interest

Xie lab is interested in plant hormone biology, with a special focus on perception and signaling mechanisms of jasmonate (JA) and strigolactone (SL). Xie lab has revealed perception mechanisms for JA and SL: COI1 serves as a JA receptor, which binds active JA molecules to form a new platform that recruits JAZ repressors for degradation to trigger JA-regulated plant defense and development; D14 acts as a non-canonical receptor for SL with dual functions of enzyme and receptor, which hydrolyzes SL, undergoes significant conformation change to form a new platform with the lid-closed cavity that recruits signal components (such as the F-box protein D3/MAX2 and repressor protein D53/SMXLs) to trigger SL responses.

Courses offered

Plant Biology, Plant Molecular Generics Biology, Scientific Writing

Selected publications

1. Wang J, Pei G, Wang Yu, Wu D, Liu X, Li G, He J, Zhang X, Shan X, Li P, Xie D. Phase separation of the nuclear pore complex facilitates selective nuclear transport to regulate plant defense against pathogen and pest invasion. Mol Plant, 2023, 16(6): 1016-1030.

2. Hu S, Yu K, Yan J, Shan X, Xie D. Jasmonate perception: Ligand-receptor interaction, regulation, and evolution. Mol Plant, 2023, 16(1): 23-42.

3. Yao R, Chen L, Xie D, Irreversible strigolactone recognition: a non-canonical mechanism for hormone perception, Current Opinion in Plant Biology, 2018, 45(Pt A): 155-161.

4. Yan J, Yao R, Chen L, Li S, Gu M, Nan F, Xie D, Dynamic perception of jasmonates by the F-Box protein COI1, Molecular Plant, 2018, 11(10): 1237-1247.

5. Yan C, Fan M, Yang M, Zhao J, Zhang W, Su Y, Xiao L, Deng H, Xie D, Injury activates Ca2+/calmodulin-dependent phosphorylation of JAV1-JAZ8-WRKY51 complex for jasmonate biosynthesis, Molecular Cell, 2018, 70(1): 136-149.

6. Wu D, Qi T, Li W, Tian H, Gao H, Wang J, Ge J, Yao R, Ren C, Wang X, Liu Y, Kang L, Ding SW, Xie D, Viral effector protein manipulates host hormone signaling to attract insect vectors, Cell Research, 2017, 27(3): 402-415.

7. Yao R, Wang F, Ming Z, Du X, Chen L, Wang, Zhang W, Deng H, Xie D, ShHTL7 is a non-canonical receptor for strigolactones in root parasitic weeds, Cell Research, 2017, 27(6): 838-841.

8. Yao R, Ming Z, Yan L, Li S, Wang F, Ma S, Yu C, Yang M, Chen L, Chen L, Li Y, Yan C, Miao D, Sun Z, Yan J, Sun Y, Wang L, Chu J, Fan S, He W, Deng H, Nan F, Li J, Rao Z, Lou Z, Xie D, DWARF14 is a non-canonical hormone receptor for strigolactone, Nature, 2016, 536(7617): 469-473.

9. Qi T, Wang J, Huang H, Liu B, Gao H, Liu Y, Song S, Xie D, Regulation of jasmonate-induced leaf senescence by antagonism between bHLH Subgroup IIIe and IIId factors in Arabidopsis, Plant Cell, 2015, 27: 1634-1649.

10. Qi T, Huang H, Song S, Xie D, Regulation of jasmonate-mediated stamen development and seed production by a bHLH-MYB complex in Arabidopsis, Plant Cell, 2015, 27(6): 1620-1633.

11. Qi T, Huang H, Wu D Yan J, Qi Y, Song S, Xie D, Arabidopsis DELLA and JAZ proteins bind the WD-repeat/bHLH/MYB complex to modulate gibberellin and jasmonate signaling synergy, Plant Cell, 2014, 26(3): 1118-1133.

12. Song S, Huang H, Gao H, Wang J, Wu D, Liu X, Yang S, Zhai Q, Li C, Qi T, Xie D, Interaction between MYC2 and ETHYLENE INSENSITIVE3 modulates antagonism between jasmonate and ethylene signaling in Arabidopsis, Plant Cell, 2014, 26(1): 263-279.

13. Hu P, Zhou W, Cheng Z, Fan M, Wang L, Xie D, JAV1 controls jasmonate-regulated plant defense, Molecular Cell, 2013, 50(4): 504-515.

14. Yan J, Li H, Li S, Yao R, Deng H, Xie Q, Xie D, The Arabidopsis F-Box protein CORONATINE INSENSITIVE1 is stabilized by SCFCOI1 and degraded via the 26S proteasome pathway, Plant Cell, 2013, 25(2): 486-498.

15. Yan J, Zhang C, Gu M, Bai Z, Zhang W, Qi T, Cheng Z, Peng W, Luo H, Nan F, Wang Z, Xie D, The Arabidopsis CORONATINE INSENSITIVE1 protein is a jasmonate receptor, Plant Cell, 2009, 21(8): 2220-2236.

Contact information

Tel：+86-10-62781575 (office); 62773664 (lab)

Fax：+86-10-62798201