Yi ZHONG Ph.D.
Professor
1985-1991 PhD., Department of Biology, University of Iowa, Iowa City, IA, USA.
1982-1985 M.S., Department of Biotechnology and Biological Science, Tsinghua University, Beijing, China.
1978-1982 B.S., Department of Engineering Physics, Tsinghua University, Beijing, China.
2015-present Professor, School of Life Sciences, Tsinghua University, Beijing, China.
2001-2015 Chair Professor, School of Life Sciences, Tsinghua University, Beijing, China.
2004-2015 Professor, Cold Spring Harbor Lab. Cold Spring Harbor. USA.
1998-2004 Associate Professor, Cold Spring Harbor Lab. Cold Spring Harbor. USA.
1995-1998 Senior Staff Investigator, Cold Spring Harbor Lab. Cold Spring Harbor. USA.
1992-1995 Staff Investigator, Cold Spring Harbor Lab. Cold Spring Harbor, USA.
Research interest
We study neural mechanism of learning and memory using genetics, electrophysiology, behavior and imaging. We firstly reveal the molecular mechanism of active forgetting and will further explore related researches. We also study human memory-related diseases, such as Alzheimer's disease, Autism, and Schizophrenia, and make efforts to develop potential drugs.
Selected publications
Lei, B., Lv, L., Hu, S., Tang, Y., and Zhong, Y*. (2022). Social experiences switch states of memory engrams through regulating hippocampal Rac1 activity. Proc Natl Acad Sci U S A 119, e2116844119.
Lei, B., Kang, B., Lin, W., Chen, H., Hao, Y., Ma, J., Shi, S., and Zhong, Y*. (2022). Adult newborn granule cells confer emotional state-dependent adaptability in memory retrieval. Science advances 8, eabn2136.
Lv, L., Liu, Y., Xie, J., Wu, Y., Zhao, J., Li, Q., and Zhong, Y*. (2019). Interplay between alpha2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory. Nature communications 10, 5313.
Zhang, X., Li, Q., Wang, L., Liu, Z.J., and Zhong, Y*. (2018). Active Protection: Learning-Activated Raf/MAPK Activity Protects Labile Memory from Rac1-Independent Forgetting. Neuron 98, 142-155 e144.
Dong, T., He, J., Wang, S., Wang, L., Cheng, Y., and Zhong, Y*. (2016). Inability to activate Rac1-dependent forgetting contributes to behavioral inflexibility in mutants of multiple autism-risk genes. Proc Natl Acad Sci U S A 113, 7644-7649.
Wang, L., Chiang, H.C., Wu, W., Liang, B., Xie, Z., Yao, X., Ma, W., Du, S., and Zhong, Y*. (2012). Epidermal growth factor receptor is a preferred target for treating amyloid-beta-induced memory loss. Proc Natl Acad Sci U S A 109, 16743-16748.
Shuai, Y.C., Lu, B.Y., Hu, Y., Wang, L.Z., Sun, K., and Zhong, Y*. (2010). Forgetting Is Regulated through Rac Activity in Drosophila. Cell 140, 579-589.
Pagani, M.R., Oishi, K., Gelb, B.D., and Zhong, Y*. (2009). The Phosphatase SHP2 Regulates the Spacing Effect for Long-Term Memory Induction. Cell 139, 186-198.
Contact information
Phone：010-62772273
E-mail：zhongyithu@tsinghua.edu.cn
