Haifeng WANG, Ph.D.

Assistant Professor

2000-2004     B.S. China Agricultural University
2004-2007     M.S.  Tsinghua University
2007-2013     Ph.D, University of California, Davis, USA
2013-2014     Postdoctoral researcher, Stanford University, USA
2021-present  Assistant Professor, School of Life Sciences, Tsinghua University
2021-present  Principal  investigator, Center for Life Sciences, Tsinghua University

●  研究兴趣、领域：

We are interested in developing and using CRISPR technologies to study cell and developmental biology and to address disease-related mechanism, and applying these tools to medical diagnosis and therapy. We mainly focus on:

(1) Developing CRISPR tools to study the regulatory mechanisms of 3D genome and transcriptome in living cells.

(2) Applying new tools to investigate the spatiotemporal dynamics of the 3D genome and transcriptome and to understand the mechanism of gene regulation during disease and development.

(3) Precision medicine: developing diagnostic and therapeutical approaches for diseases related to genomic or transcriptome abnormalities.

●  代表性论文：

Wang H, Han M, Qi LS, Engineering 3D genome organization, Nature Review Genetics, 2021 Feb;  PMID: 33558716;
Wang H, Nakamura M, Abbott TR, Zhao D, Luo K, Yu C, Nguyen CM, Lo A, Daley PT, La Russa M, Liu Y, Qi LS, CRISPR-mediated live imaging of genome editing and transcription. Science, 2019 Sep; Vol. 365, Issue 6459, pp. 1301-1305.
Wang H, Xu X, Nguyen CM, Liu Y, Gao Y, Lin X, Daley PT, Kipniss NH, La Russa M, Qi LS, CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization. Cell, 2018 Oct; 175, 1405-1417 e1414.
Liu Y, Yu C, Daley T, Wang F, Cao W, Lin X, Still C, Bhate S, Liu H, Zhao D, Wang H, Xie X, Ding S, Wong WH, Wernig M, Qi LS, CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming. Cell Stem Cell, 2018 Nov; 23(5):758-771.e8.
Kipniss N, Dingal PCD, Abbott T, Gao Y, Wang H, Dominguez A, and Labanieh L, Qi LS, Engineering Cell Sensing and Responses Using a GPCR-Coupled CRISPR-Cas System. Nature Communications, 2017 Dec; 2212.
Wang H, La Russa M, Qi LS, CRISPR-Cas9 in genome editing and beyond. The Annual Review of Biochemistry, 2016 Aug; Vol. 85: 227-264.
Wang H, Brust-Mascher I and Scholey JM, The microtubule cross-linker Feo controls the midzone stability, motor composition, and elongation of the anaphase B spindle in Drosophila embryos. Molecular Biology of the Cell. 2015 Apr 15; 26(8):1452-62. PMID: 25694445. Selected as the Cover paper.
Wang H, Brust-Mascher I and Scholey JM, Sliding filaments and mitotic spindle organization, Nature Cell Biology, 2014 Aug; 16(8):737-739. PMID: 25082196
Wang H, Brust-Mascher I, Civelekoglu-Scholey G and Scholey JM, Patronin mediates a switch from kinesin-13-dependent poleward flux to anaphase B spindle elongation, Journal of Cell Biology, 2013 Oct; 203(1):35-46. PMCID: PMC3798244.

●  联系方式：

Email：hfwang(at)mail.tsinghua.edu.cn

Lab Website：http://www.wanglab-thu.org.cn/