Xinquan WANG Ph.D.
Professor
1990 – 1995 / Fudan University / B.S
1995 – 2000 / Institute of Biophysics, Chinese Academy of Sciences / P h .D.
2001 – 2003 / Institute of Biophysics, Chinese Academy of Sciences / Research Associate
2003 – 2008 / Stanford University / Postdoctoral Researcher
2008 – 2013 / School of Life Sciences, Tsinghua University / Tenure Track Associate Professor
2013 - present / School of Life Sciences, Tsinghua University / Tenured Professor
Research interest
We investigate cell surface receptor recognition and activation using structural biology approaches. One major research interest in our laboratory is to elucidate the receptor-ligand interactions and activation in the interleukin 1 (IL-1) and other cytokine families that play important roles in host inflammatory response and regulation. We also study macromolecular interactions that mediate the cell entry of highly pathogenic coronaviruses and influenza viruses and host neutralization by potent antibodies.
Selected publications
1. Zhang S, Liang Q, He X, Zhao C, Ren W, Yang Z, Wang Z, Ding Q, Deng H, Wang T*, Zhang L*, Wang X*. Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2. Cell Res. (2022) 32(3):315-318.
2. Ge J, Wang R, Ju B, Zhang Q, Sun J, Chen P, Zhang S, Tian Y, Shan S, Cheng L, Zhou B, Song S, Zhao J, Wang H, Shi X, Ding Q, Liu L, Zhao J, Zhang Z*, Wang X*, Zhang L*. (2021) Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry. Nature Communications, 12(1):250.
3. Zhang, S., Qiao, S., Yu, J., Zeng, J. & Wang, X*.(2021). Bat and pangolin coronavirus spike glycoprotein structures provide insights into sars-cov-2 evolution. Nature Communications, 12(1), 1607.
4. Yu J, Qiao S, Guo R & Wang X*. Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution. Nat Commun 11, 3070, doi: 10.1038/s41467-020-16876-4 (2020)
5. Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, Zhang Q, Shi X, Wang Q, Zhang L & Wang X*. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature. Mar 30. doi: 10.1038/s41586-020-2180-5. [Epub ahead of print] (2020).
6. Zhou H, Chen Y, Zhang S, Niu P, Qin K, Jia W, Huang B, Zhang S, Lan J, Zhang L, Tan W & Wang X*. Structural definition of a neutralization epitope on the n-terminal domain of mers-cov spike glycoprotein. Nat Commun 10, 3068, doi:10.1038/s41467-019-10897-4 (2019).
7. Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S & Wang X*. Functional relevance of interleukin-1 receptor inter-domain flexibility for cytokine binding and signaling. Structure 27, 1296-1307 e1295, doi:10.1016/j.str.2019.05.011 (2019).
8. Zhang S, Zhou P, Wang P, Li Y, Jiang L, Jia W, Wang H, Fan A, Wang D, Shi X, Fang X, Hammel M, Wang S, Wang X* & Zhang L. Structural definition of a unique neutralization epitope on the receptor-binding domain of mers-cov spike glycoprotein. Cell Rep 24, 441-452, doi:10.1016/j.celrep.2018.06.041 (2018).
9. Song W, Gui M, Wang X* & Xiang Y. Cryo-em structure of the sars coronavirus spike glycoprotein in complex with its host cell receptor ace2. PLoS Pathog 14, e1007236, doi:10.1371/journal.ppat.1007236 (2018).
10. Gui M, Song W, Zhou H, Xu J, Chen S, Xiang Y & Wang X*. Cryo-electron microscopy structures of the sars-cov spike glycoprotein reveal a prerequisite conformational state for receptor binding. Cell Res 27, 119-129, doi:10.1038/cr.2016.152 (2017).
11. Jiang L, Wang N, Zuo T, Shi X, Poon KM, Wu Y, Gao F, Li D, Wang R, Guo J, Fu L, Yuen KY, Zheng BJ, Wang X* & Zhang L. Potent neutralization of mers-cov by human neutralizing monoclonal antibodies to the viral spike glycoprotein. Sci Transl Med 6, 234ra259, doi:10.1126/scitranslmed.3008140 (2014).
12. Wang N, Shi X, Jiang L, Zhang S, Wang D, Tong P, Guo D, Fu L, Cui Y, Liu X, Arledge KC, Chen YH, Zhang L & Wang X*. Structure of mers-cov spike receptor-binding domain complexed with human receptor dpp4. Cell Res 23, 986-993, doi:10.1038/cr.2013.92 (2013).
13. Wang D, Huang B, Zhang S, Yu X, Wu W & Wang X*. Structural basis for r-spondin recognition by lgr4/5/6 receptors. Genes Dev 27, 1339-1344, doi:10.1101/gad.219360.113 (2013).
14. Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S & Wang X*. Structural insights into the interaction of il-33 with its receptors. Proc Natl Acad Sci U S A 110, 14918-14923, doi:10.1073/pnas.1308651110 (2013).
15. Wang D, Zhang S, Li L, Liu X, Mei K & Wang X*. Structural insights into the assembly and activation of il-1beta with its receptors. Nat Immunol 11, 905-911, doi:10.1038/ni.1925 (2010).
Contact information
E-mail: xinquanwang@mail.tsinghua.edu.cn
