Wei Wu   Ph.D.

Professor

1987-1991, Sichuan University, B.S.

1991-1994, Sichuan University, M.S.

1996-2001, Heidelberg University, Germany, Ph.D

2001-2005, German Cancer Research Center (DKFZ), Postdoc

2005-present, Professor of Tsinghua University

Research interest

Adult stem cells maintain tissue homeostasis via proliferation and differentiation, and, may lead to tumor development when driver mutations accumulate. Using mice and organoid culture technology, combined with genome editing and chemical biology methods, we study the epigenetic mechanisms underline the differentiation or tumorigenesis of intestinal stem cells, and hope to identify potential therapeutic targeting approaches.

Selected publications

1. Su S, Yang Z, Gao H, Yang H, Zhu S, An Z, Wang J, Li Q, Chandarlapaty S, Deng H, Wu W*, Rao Y*. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582.
2. An Z, Lv W, Su S, Wu W*, Rao Y*. Developing potent PROTACs tools for selective degradation of HDAC6 protein. Protein Cell. 2019 Jan 2.
3. Zhu G, Fan Z, Ding M, Zhang H, Mu L, Ding Y, Zhang Y, Jia B, Chen L, Chang Z, Wu W. An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis. Oncogene. 2015 Mar 9.
4. Ding Y, Su S, Tang W, Zhang X, Chen S, Zhu G, Liang J, Wei W, Guo Y, Liu L, Chen YG, Wu W. Enrichment of the β-catenin-TCF complex at the S and G2 phases ensures cell survival and cell cycle progression. J Cell Sci. 2014 Nov 15;127(22):4833-45.
5. Zhu G, Fan Z, Ding M, Mu L, Liang J, Ding Y, Fu Y, Huang B, Wu W. DNA Damage Induces the Accumulation of Tiam1 by Blocking β-TrCP-dependent Degradation. J Biol Chem. 2014 May 30;289(22):15482-15494.
6. Su X, Zhu G, Ding X, Lee SY, Dou Y, Zhu B, Wu W#, and Li H#. Molecular basis underlyinghistone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. Genes Dev. 2014 Mar 15;28(6):622-36. (#: co-corresponding author) (Featured by F1000)
7. Fu Y, Huang B, Shi Z, Han J, Wang Y, Huangfu J, Wu W. SRSF1 and SRSF9 RNA binding proteins promote Wnt signaling-mediated tumorigenesis by enhancing β-catenin biosynthesis. EMBO Mol Med. 2013 May;5(5):737-50.
8. Zhu G, Wang Y, Huang B, Liang J, Ding Y, Xu A, Wu W. A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells. Oncogene. 2012 Feb 23;31(8):1001-12.
9. Liang J, Fu Y, Cruciat CM, Jia S, Wang Y, Tong Z, Tao Q, Ingelfinger D, Boutros M, Meng A, Niehrs C, Wu W. Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation. Mol Cell Biol. 2011 Jul;31(13):2577-90.
10. Chai G, Ma C, Bao K, Zheng L, Wang X, Sun Z, Salo E, Adell T, Wu W. Complete functional segregation of planarian beta-catenin-1 and -2 in mediating Wnt signaling and cell adhesion. J Biol Chem. 2010 Jul 30;285(31):24120-30.
11. Wang Y, Fu Y, Gao L, Zhu G, Liang J, Gao C, Huang B, Fenger U, Niehrs C, Chen YG, Wu W. Xenopus skip modulates Wnt/beta-catenin signaling and functions in neural crest induction. J Biol Chem. 2010 Apr 2;285(14):10890-901.
12. *Davidson G, *Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature. 2005 Dec 8;438(7069):867-72. (*equal contribution)
13. Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W. Rspo2 is a secreted activator of Wnt/β-catenin signalling and is required for Xenopus myogenesis. Dev Cell. 2004 Oct; 7(4): 525-34.
14. *Mao B, *Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 2001 May 17; 411(6835):321-5. (*equal contribution)

Contact information

School of Life Sciences, Tsinghua University, 100084, Beijing
Tel：+86-10-62797127
E-mail: wwu(at)tsinghua.edu.cn